I’ve been reading Fat Chance by Robert H. Lustig MD. Slow read – heavy on the biochemistry. His view-point is from an Endocrinologist – so everything must be explained by the interaction of all of the parts and processes of your body.  I’m about 50% into it.  Once I finish it off, I’ll provide more information.  But – this particular paragraph about the value of exercise, caught my attention.

And the biggest problem of all: the beneficial effects of exercise, while excellent for your body and your metabolism, are relatively short-lived, and have to be frequent and sustained. Studies demonstrate that levels of PPAR-gamma coactivator 1-alpha (PGC-1α; the protein in muscle cells that turns on all the good muscle metabolic effects and tells the mitochondria to divide) decline within a day of cessation of exercise, and insulin sensitivity returns to baseline within fifteen days.  So, those of you weekend warriors who think you’re doing yourself some good— it may not be as good as you think. If you’re going to use exercise as your protection against chronic disease, you’ll have to be consistent about it.  Lustig, Robert H. (2012-12-27). Fat Chance: Beating the Odds Against Sugar, Processed Food, Obesity, and Disease (p. 148). Penguin Group US. Kindle Edition.

There just is never a time you can put your feet up and relax.  A two-week vacation had better include some real active exercise.